A., 2009, Handbook of Cosmetics Science and Technology. Y., 2017, Гўв‚¬ЛњFormulation of Emulgel Ethanol Extract of Mullberry (Morus alba L.) with Various Concentration of Span 80 and Tween 80Гўв‚¬в„ў, Journal of Pharmaceutical and Medicinal Sciences, 2(2), 77-80.ДЄnsari, S. In vivo activity test showed thatВ emulgel containing 20% and 30% grape seed oil have wound healing activity that statistically different compared with control (P0.05).ДЄisyah, A.N., Zulham, Nurul, A. The emulgel containing grape seed oil with HLB value 8, has good physical, sterility, and stability characteristics. Wound healing activity test of selected formula was done on seven groups of male Wistar rats. The formulation then subjected to physical evaluations including organoleptic, pH, spreadability, viscosity and rheology, sterility, and stability tests. The emulgel was made using combination Tween 80 and Span 80 as emulgator and carbomer as gelling agent with variation of oil concentration (10%, 20% and 30%).

The research was begin with grape seed oil characterization and required HLB determination. The purpose of this study is formulate emulgel containing grape seed oil with good physical characteristic and observed the wound healing activities of the oil and formulated emulgel. Rute pemberian oral menjadi rute pemberian yang paling popular dan paling sering digunakan dalam pengobatan pasien.Grape seed oil has wound healing activity since contains compounds such as flavonoids, polyphenols, saponins and linoleic acid. Namun, salah satu masalah yang sering ditemui pada pasien dalam melakukan terapi dengan rute pemberian oral adalah adanya tidak kepatuhan dalam mengkonsumsi obat. Rasa yang tidak enak serta kemampuan beberapa pasien terutama lansia dan anak kecil yang tidak dapat menelan tablet menjadi alasannya. Effervescent menjadi salah satu alternatif yang dapat digunakan dalam mengatasi masalah tersebut. Review ini akan menggambarkan beberapa formulasi dan evaluasi sediaan effervescent serta penerapannya dalam beberapa sistem pemberian obat terbaru. Pencarian literatur dilakukan menggunakan bantuan situs pencarian jurnal online Pubmed, dan ditemukan 21 artikel dari 265 artikel yang sesuai dengan kriteria inklusi. Dari 21 artikel ini, 16 diantaranya adalah formulasi tablet effervescent. Metode granulasi basah diketahui merupakan metode terbaik dalam formulasi effervescent karena dapat meningkatkan daya alir serta indeks kompresibilitasnya. Asam sitrat dan natrium karbonat menjadi kombinasi agen effervescent yang paling sering digunakan. Formulation and evaluation of effervescent tablets: a review. Drug-delivery products and the Zydis fast-dissolving dosage form. doi:10.1002/pdi.606ДЄgyilirah GA, Green M, duCret R, Banker GS. Evaluation of the gastric retention properties of a cross-linked polymer coated tablet versus those of a non-disintegrating tablet. Encyclopedia of Pharmaceutical Technology. Shirsand SB, Suresh S, Jodhana LS, Swamy P V. Formulation design and optimization of fast disintegrating Lorazepam tablets by effervescent method. Pengantar Bentuk Sediaan Farmasi Edisi IV. Effervescent tablet formulation for enhanced patient compliance and the therapeutic effect of risperidone. Kamboj M, Goyal S, Rakha P, Arora G, Dureja H, Nagpal M. Formulation and evaluation of metformin oro-dispersible tablets. Nanopharmaceutics Innovations in Gene Therapy: Moving Towards Non-Viral and Non-Invasive Delivery Methods. Patel BP, Patel JK, Rajput GC, Thakor RS. Formulation and evaluation of mouth dissolving tablets of cinnarizine. Wening K, Laukamp EJ, Thommes M, Breitkreutz J. Individual oral therapy with immediate release and effervescent formulations delivered by the solid dosage pen.

Formulation, characterization and physicochemical evaluation of potassium citrate effervescent tablets. Romero-de Soto MD, GarcГa-Salas P, FernГЎndez-Arroyo S, Segura-Carretero A, FernГЎndez-Campos F, Clares-Naveros B. Antioxidant activity evaluation of new dosage forms as vehicles for dehydrated vegetables. Formulation, characterization and physicochemical evaluation of ranitidine effervescent tablets. Formulation, characterization and physicochemical evaluation of amoxicillin effervescent tablets. Nazir SR, Ambreen G, Irfan HM, Bashir S, Rauf A.ДЄpplication of SeDeM Expert system in formulation development of effervescent tablets by direct compression. Development and formulation of metformin (Antidiabetic) effervescent Granules: to increase patient compliance and its stability study. Formulation and optimization of orodispersible tablets of flutamide. Saudi Pharm J SPJ Off Publ Saudi Pharm Soc. Sarfraz RM, Khan HU, Mahmood A, Ahmad M, Maheen S, Sher M.

Formulation and evaluation of mouth disintegrating tablets of atenolol and atorvastatin. Novel levocetirizine HCl tablets with enhanced palatability: synergistic effect of combining taste modifiers and effervescence technique.

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